Our services
Multi-API/Synergistic combinations
Identification of synergistic combinations of drugs and APIs
Drug development company is looking to develop a differentiating drug
combination product for particular indication?
Particular API is at the end of its patent life cycle and pharma company is looking to extend its life cycle via a novel synergistic combination?
Design of multi API new drug formulations for superior efficacy
Generic pharma has a portfolio of single API agents and they are looking to develop drug combinations with intention to lower dose-strength or improved bioavailability or different dosing regimen for 505(b)(2) regulatory pathway?
Clinical project rescue with synergistic combinations
Company is developing or has in-licensed a novel molecule and it fails to show expected efficacy in Phase 2 trial. Can we combine it with other APIs in a synergistic fashion or reposition to avoid risk of attrition and loss?
Solution
Our exhaustive biomarker profiling of the drug coupled with our unique fish-net principle approach enables the quantification of relative relevance of drug molecules in combinations.
Recommendations of potential synergistic API including justifications and ranking based on clients’ requirement will be provided.
Impact & Benefits
Addition of a market differentiating drug product with higher efficacy to the clients’ portfolio
Preserving value of the client's novel molecule via clinical rescue
Market exclusivity via 505(b)(1) or 505(b)(2) regulatory pathway